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Annual Session 2022

AS22B24 - Short-term effects of mechanical loading on the transdifferentiation of condylar chondrocytes

May 21, 2022 1:20pm ‐ May 21, 2022 1:40pm

Credits: None available.


Various studies have shown that treatments can alter condylar growth direction. While the structural adaptations are now well established, the cellular process controlling these changes is not well understood. It was recently discovered that transdifferentiation of chondrocytes into bone cells explains most of the prenatal and early postnatal condylar growth that occurs; its role during later postnatal growth remains unknown. This presentation will outline the effects of mechanical loading on chondrocyte-derived osteogenesis during later postnatal condylar growth using a short-term mandibular laterotrusion model.

Learning Objectives:

  • Describe endochondral ossification and cell transdifferentiation as it relates to condylar growth.
  • Explain the gross, radiographic, and histologic results of laterotrusion on the mandible.
  • Discuss the short-term cellular changes that occur during structural adaptation of the condyle.



Credits: None available.

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