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Annual Session 2022

AS22B25 - Investigating PRG4 re-expression as a treatment for TMJ degenerative diseases

May 21, 2022 1:40pm ‐ May 21, 2022 2:00pm

Credits: None available.


Proteoglycan 4 (PRG4, also known as lubricin) is a mucin-like glycoprotein that contributes to the lubrication of cartilage surfaces. PRG4 is present in the TMJ and plays an essential role in its maintenance. However, there are few studies regarding biomechanical characterization of PRG4-deficient TMJ, which is critical to fully characterize the extent of TMJ degeneration, as is understanding the effect of restoring PRG4 expression on TMJ integrity. This presentation will discuss the role PRG4 plays in TMD and the effects of PRG4 re-expression on TMJ cartilage degeneration in PRG4 deficient mice.

Learning Objectives:

  • To demonstrate the role of PRG4 expression in TMD through characterization of TMJ cartilage at various stages of disease.
  • To determine effects of restoration of PRG4 gene function in PRG4 deficient mice on TMJ cartilage degeneration.
  • To evaluate the biomechanical changes of cartilage in TMJ with or without PRG4 gene function.



Credits: None available.

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