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Annual Session 2022

AS22B28 - How does Alendronate affect orthodontic tooth movement in osteogenesis imperfecta: an in-vivo study on a mice model

May 21, 2022 1:40pm ‐ May 21, 2022 2:00pm

Credits: None available.


In addition to bone deformities, patients with Osteogenesis Imperfecta (OI) have a higher index of orthodontic treatment need than controls. Patients with OI have severe malocclusions with reverse overjet, open bite, and require orthodontic treatment. Bisphosphonates are the most common therapeutic agents used in OI patients. However, the current literature lacks information regarding the effects of orthodontic tooth movement in Osteogenesis Imperfecta under the influence of Bisphosphonates. This lecture will answer the following questions with male and female OI mice. Can orthodontic tooth movement be performed safely in OI? How Alendronate affects orthodontic tooth movement in an OI mice model as compared to saline? How does the alveolar bone modeling/remodeling occur in an OI mice model with and without the treatment with alendronate?

Learning Objectives:

  • To show that there is reduced orthodontic tooth movement and increased hyalinization zones in an OI mice model with alendronate as compared to saline.
  • To demonstrate that alveolar bone modeling/remodeling in reduced and higher bone volume is observed with alendronate treatment.
  • To assess that the intensity of collagen fibers of the periodontal ligament is higher in the alendronate male and female mice compared with saline male and female OI mice.



Credits: None available.

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