Gingival crevicular fluid (GCF) has been widely investigated as a potential source of biomarkers for an individual’s oral and general health information. Various biomolecules presented in GCF were reported as potential biomarkers for orthodontic tooth movement (OTM). MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation. Secretory miRNAs are being investigated as diagnostic as well as therapeutic tools in many pathological conditions. In this study, we investigated the expression profile of secretory miRNA-29 in GCF during OTM in human.
Demonstrate the presence of secretory miRNAs in GCF.
Investigate the expression profile of secretory miRNA-29 in GCF during canine retraction in human