Early diagnosis of external root resorption is an important clinical goal in orthodontics. To date, radiography and computed tomography (CT) have been the standard techniques used by orthodontists to diagnose and monitor external root resorption. Nevertheless, the cost and the risks associated with radiation exposure make it difficult for routine use in dentistry. In addition, X-rays and CT scans have also many pitfalls including the fact that they do not indicate if the process of root resorption is ongoing or historical. Given these limitations, there is an indication for a more sensitive and safer diagnostic method for detecting root resorption. New technology platforms developed over the past few years have given clinical researchers the ability to identify novel biomarkers of root resorption in oral fluids. The future of this field will depend on further validation of specific markers and their incorporation into state-of-the-art assays that are reliable and cost-effective for broad implementation in clinical practice.
Recall the pathogenesis of root resorption.
Discuss current biomarkers that may aid in root resorption diagnosis.
Recognize the challenges associated with validating potential biomarkers of root resorption.