Newly evolving comprehensive genetic testing is a game changer for clinical medical and dental practice. For orthodontists, there are times when clinically relevant genomic information enhances a personalized orthodontic treatment plan. Recognizing skeletal, facial and oral deviations, major and minor malformations as well as careful family and medical histories can offer clues to a genetic condition. Follow-up searches of databases and literature often suggest closer evaluation and referral to a clinical geneticist. This lecture will review recognition of unusual patterns in an orthodontic evaluation, when to refer to a clinical geneticist for evaluation, genetic testing and responding to genetic information acquired such as referrals, integrating new personalized protocols and limitations of interpretation.
Recognize unusual patterns in phenotypes, clinical records and family history that warrant closer look in genetic databases and literature.
Determine when to refer to a clinical geneticist for targeted genetic testing or Clinical Genome and Exome Sequencing (CGES).
Respond to genetic information collected and manage/adjust treatment where indicated.