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Newly evolving comprehensive genetic testing is a game changer for clinical medical and dental practice. For orthodontists, there are times when clinically relevant genomic information enhances a personalized orthodontic treatment plan. Recognizing skeletal, facial and oral deviations, major and minor malformations as well as careful family and medical histories can offer clues to a genetic condition. Follow-up searches of databases and literature often suggest closer evaluation and referral to a clinical geneticist. This lecture will review recognition of unusual patterns in an orthodontic evaluation, when to refer to a clinical geneticist for evaluation, genetic testing and responding to genetic information acquired such as referrals, integrating new personalized protocols and limitations of interpretation.
Learning Objectives:
Recognize unusual patterns in phenotypes, clinical records and family history that warrant closer look in genetic databases and literature.
Determine when to refer to a clinical geneticist for targeted genetic testing or Clinical Genome and Exome Sequencing (CGES).
Respond to genetic information collected and manage/adjust treatment where indicated.
