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2017 Annual Session Conference

AS17B39D - Thomas M. Graber Award of Special Merit Lecture: Altering Osteoclasts In Utero Leads to Changes in Mandibular Lengths in Adult Mice

Apr 24, 2017 9:10am ‐ Apr 24, 2017 9:30am


The role of environmental and local factors in determination of mandibular length is unknown, but the balance between bone formation and resorption during development likely influences mandibular length. The lecture will review the results found in two murine models where osteoclast function is inhibited. The data presented will lay the foundation for future experiments to further understand the role of osteoclasts in determination of mandibular length.

Learning Objectives:

  • Interpret how osteoclast function is inhibited in the two mouse models described.
  • Recognize the importance of bone metabolism in proper development of mandibular growth.


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