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Tooth movement is a process of cellular responses of effector cells: periodontal ligament and alveolar bone cells to orthodontic forces. This process is strictly regulated at the transcriptional, post-transcriptional and post-translational levels. MicroRNAs (miRNAs) are short non-coding RNAs that are important regulators of post-transcriptional gene expression in osteoblast/clast functions. In this study, we evaluated the effects of miRNA-29 underexpression during tooth movement in mice and gained insights into the mechanisms of how the miRNA-29 family plays a role in tooth movement via osteoclast function.
Learning Objectives:
Recognize the roles of miRNA-29 on osteoclasts during tooth movement in a mouse model.
Understand the concept of a sponge transgenic mouse model and a tooth movement model in a mouse model.
