The accreditors of this session require that you periodically check in to verify that you are still attentive.
Please click the button below to indicate that you are.
Tooth movement is a process of cellular responses of effector cells: periodontal ligament and alveolar bone cells to orthodontic forces. This process is strictly regulated at the transcriptional, post-transcriptional and post-translational levels. MicroRNAs (miRNAs) are short non-coding RNAs that are important regulators of post-transcriptional gene expression in osteoblast/clast functions. In this study, we evaluated the effects of miRNA-29 underexpression during tooth movement in mice and gained insights into the mechanisms of how the miRNA-29 family plays a role in tooth movement via osteoclast function.
Learning Objectives:
Recognize the roles of miRNA-29 on osteoclasts during tooth movement in a mouse model.
Understand the concept of a sponge transgenic mouse model and a tooth movement model in a mouse model.