Description
Orthodontic tooth movement depends on efficient remodeling of surrounding alveolar bone. While a well-controlled inflammatory response is essential during such biological processes, the precise mechanism by which how inflammation is tightly regulated hasn’t been fully understood. Autophagy, a conserved catabolic pathway, has been shown to protect cells from excessive long-lasting inflammation in nervous systems and disease conditions. We set out to test the role autophagy may play in regulating inflammation during OTM.
Learning Objectives:
- Establish the correlation of autophagy and inflammation in mice at different time points during tooth movement after spring loading.
- Examine alteration of inflammation and tooth movement upon administration of autophagy modifying drug, rapamycin.
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