Orthodontic tooth movement depends on efficient remodeling of surrounding alveolar bone. While a well-controlled inflammatory response is essential during such biological processes, the precise mechanism by which how inflammation is tightly regulated hasn’t been fully understood. Autophagy, a conserved catabolic pathway, has been shown to protect cells from excessive long-lasting inflammation in nervous systems and disease conditions. We set out to test the role autophagy may play in regulating inflammation during OTM.
Establish the correlation of autophagy and inflammation in mice at different time points during tooth movement after spring loading.
Examine alteration of inflammation and tooth movement upon administration of autophagy modifying drug, rapamycin.