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2019 Annual Session Conference

Thomas M. Graber Award of Special Merit: The role of autophagy during orthodontic tooth movement

May 6, 2019 8:40am ‐ May 6, 2019 9:00am


Orthodontic tooth movement depends on efficient remodeling of surrounding alveolar bone. While a well-controlled inflammatory response is essential during such biological processes, the precise mechanism by which how inflammation is tightly regulated hasn’t been fully understood. Autophagy, a conserved catabolic pathway, has been shown to protect cells from excessive long-lasting inflammation in nervous systems and disease conditions. We set out to test the role autophagy may play in regulating inflammation during OTM.

Learning Objectives:

  • Establish the correlation of autophagy and inflammation in mice at different time points during tooth movement after spring loading.
  • Examine alteration of inflammation and tooth movement upon administration of autophagy modifying drug, rapamycin.


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