Bisphosphonate & Denosumab Update: The DOs & DON’Ts of Orthodontic Procedures

Osteoblastic (bone building) and osteoclastic (bone resorbing) processes are needed for predictable success of most orthodontic procedures. Bisphosphonates and denosumab, two completely different drugs, have similar effects which can severely decrease normal bone turnover. It is important to understand the reported literature and how these medications have the ability to impact associated orthodontic procedures, such as extractions, tooth movement, maxillary expansion, bone augmentation, and dental implants. Predict how other drugs affect bone turnover and the subsequent success of orthodontic treatment.