Biological and Immunological Processes Underlying Orthodontic Tooth Movement in Regenerative Sites

Pre-orthodontic alveolar bone regeneration can improve tooth support and optimize orthodontic tooth movement into bony defects. Does the ability to move teeth through periodontal regenerated tissues offer the same degree of predictability as moving teeth through normal “healthy” tissues? Are the biological processes underlying tooth movement into regenerated tissues different? Are they dependent on the regenerative material type? Can we improve predictability and control rate of tooth movement? Novel in-vivo mouse regeneration and orthodontic models provide answers to these dilemmas.

Learning Objectives:

• Differentiate between the biological processes underlying tooth movement in healthy and regenerated tissues.
• Choose the most suitable graft material for pre-orthodontic regeneration.
• Determine the ideal timing for force application based on the dynamics of tissue healing.